RDH14

Across TCGA patient cohorts, RDH14 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH14-associated genes across cancer lineages are MIR4438, RNU6-316P, and PNRC2P1. Each is linked with RDH14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH14-to-partner and partner-to-RDH14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4438 grouped by RDH14-low versus RDH14-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH14→partner) and Y-score (partner→RDH14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4438 →	+0.393	+7.816	<.001	.008	3	1
UCEC	RNU6-316P →	+0.337	+4.386	<.001	<.001	3	1
UCEC	PNRC2P1 →	+0.990	+3.544	.003	.005	3	1
UCEC	HIGD1AP15 →	+0.205	+3.418	<.001	.002	3	1
UCEC	RN7SL825P →	+0.415	+3.450	.001	.006	3	1
UCEC	RNA5SP419 →	+0.944	+3.077	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MIR4438 by RDH14 expression — SKCM

Explore this box plot interactively →