RDH13

Across TCGA patient cohorts, RDH13 mutation is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH13-associated genes across cancer lineages are DDAH1, SPATA5L1, and KLF5. Each is linked with RDH13 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH13-to-partner and partner-to-RDH13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDAH1 grouped by RDH13-low versus RDH13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH13→partner) and Y-score (partner→RDH13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDAH1 →	+0.756	+3.343	.008	.005	3	2
UCEC	SPATA5L1 →	+0.521	+3.394	.004	.004	3	2
UCEC	KLF5 →	+0.848	+3.330	.008	.005	3	2
UCEC	NDUFA6 →	+0.428	+3.191	.007	.009	3	2
LUSC	RN7SL680P →	+0.153	+4.625	<.001	.008	3	2
STAD	RNY4P23 →	+0.632	+3.105	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

DDAH1 by RDH13 expression — UCEC

Explore this box plot interactively →