RDH11

Across TCGA pan-cancer cohorts, RDH11 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RDH11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RDH11 RNA is repressed in tumor relative to normal tissue. In most cancer types RDH11 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where RDH11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RDH11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.093	<.001	11	view →
HNSC	Female	All	+0.940	<.001	11	view →
COAD	Female	II,III,IV	+0.727	<.001	10	view →
THCA	Male	III,IV	−0.947	<.001	9	view →
KIRP	Male	All	−0.485	<.001	7	view →
BRCA	All	III,IV	+0.643	<.001	6	view →
STAD	All	All	+0.531	<.001	5	view →
BLCA	Male	All	+0.562	.021	4	view →
UCEC	All	All	+0.549	<.001	4	view →
LIHC	Male	All	+0.605	<.001	3	view →
PRAD	All	All	+0.855	.003	2	view →
ESCA	All	All	+0.816	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RDH11–KIRC

Open the KIRC breakdown →