RDH10

Across TCGA patient cohorts, RDH10 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH10-associated genes across cancer lineages are PRAS40_pT246, XBP1, and CD49b. Each is linked with RDH10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH10-to-partner and partner-to-RDH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by RDH10-low versus RDH10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH10→partner) and Y-score (partner→RDH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.219	+2.183	.014	.035	3	1
UCEC	XBP1 →	-0.192	-3.169	.009	.019	3	1
UCEC	CD49b →	-0.390	-2.980	.008	.036	2	1
UCEC	C-Raf →	+0.211	+3.000	.004	.036	2	1
UCEC	p70-S6K →	+0.266	+3.348	.008	.005	1	1
UCEC	Rab25 →	-0.589	-3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRAS40_pT246 by RDH10 expression — UCEC

Explore this box plot interactively →