Across TCGA patient cohorts, RD3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RD3-associated genes across cancer lineages are Notch1, STAT3_pY705, and Cyclin-E2. Each is linked with RD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RD3-to-partner and partner-to-RD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RD3→partner) and Y-score (partner→RD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.216	+3.169	.005	.020	3	1
UCEC	STAT3_pY705 →	-0.459	-3.169	.001	.020	3	1
UCEC	Cyclin-E2 →	+0.231	+3.169	.012	.020	3	1
UCEC	PCNA →	+0.348	+3.169	.003	.020	2	1
UCEC	PREX1 →	-0.374	-3.000	.013	.036	2	1
UCEC	ATM →	-0.567	-3.169	.022	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

RD3 survival (RNA) · tumor vs normal (RNA) · all RD3 data types