RCVRN

Across TCGA patient cohorts, RCVRN mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RCVRN-associated genes across cancer lineages are Caveolin-1, eIF4E, and MEK1. Each is linked with RCVRN in more than 2 cancer types. Because this analysis shows association rather than direction, both RCVRN-to-partner and partner-to-RCVRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by RCVRN-low versus RCVRN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCVRN→partner) and Y-score (partner→RCVRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caveolin-1 →	-0.713	-3.169	.008	.018	3	3
COAD	eIF4E →	+0.185	+3.012	.006	.018	3	2
UCEC	MEK1 →	+0.361	+1.925	.006	.005	3	2
UCEC	p27 →	-0.157	-1.584	.046	.019	3	2
UCEC	P-Cadherin →	-0.153	-3.584	.003	.002	3	2
UCEC	4E-BP1 →	+0.204	+1.614	.036	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caveolin-1 by RCVRN expression — COAD

Explore this box plot interactively →