RCOR3

Across TCGA pan-cancer cohorts, RCOR3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RCOR3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RCOR3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RCOR3 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where RCOR3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RCOR3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.537	<.001	12	view →
PDAC	Female	II,III,IV	−0.547	<.001	10	view →
LSCC	Male	All	+0.325	<.001	7	view →
LUAD	Male	All	+0.246	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RCOR3–HNSC

Open the HNSC breakdown →