RCOR3

Across TCGA cell cohorts, RCOR3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RCOR3-associated genes across cancer lineages are SEMG2, GJD2, and TBC1D21. Each is linked with RCOR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCOR3-to-partner and partner-to-RCOR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by RCOR3-low versus RCOR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCOR3→partner) and Y-score (partner→RCOR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG2 →	+0.473	+3.878	.001	.003	3	1
LARGE_INTESTINE	GJD2 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PFN3 →	+0.138	+5.204	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SEMG2 by RCOR3 expression — LARGE_INTESTINE

Explore this box plot interactively →