Across TCGA pan-cancer cohorts, RCOR2 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RCOR2’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LSCC), where RCOR2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RCOR2 is over-expressed in tumor.
LSCC are the cancer types where RCOR2 tumor–normal differential expression is most reproducible.