RCN3

Across TCGA pan-cancer cohorts, RCN3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RCN3 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RCN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RCN3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where RCN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	33	view →
LSCC	DFS	Quartile	II,III,IV	0.488	0.902	.002	26	view →
UCEC	OS	Median	III,IV	0.494	1.000	.016	16	view →
PDAC	DFS	Quartile	III,IV	0.368	0.884	.026	6	view →
LUAD	DFS	Quartile	All	0.946	0.837	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RCN3–CCRCC (DFS)

Open the CCRCC breakdown →