RCN3

Across TCGA patient cohorts, RCN3 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RCN3-associated genes across cancer lineages are VHL, Caspase-7-cleavedD198, and EGFR_pY1173. Each is linked with RCN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCN3-to-partner and partner-to-RCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by RCN3-low versus RCN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCN3→partner) and Y-score (partner→RCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.920	-3.000	.019	.037	3	1
COAD	Caspase-7-cleavedD198 →	+1.501	+3.008	<.001	.019	3	1
COAD	EGFR_pY1173 →	-0.102	-2.957	.040	.036	2	1
COAD	c-Myc →	-0.242	-2.987	.048	.035	2	1
UCEC	PDK1_pS241 →	+0.291	+3.013	.003	.019	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

VHL by RCN3 expression — UCEC

Explore this box plot interactively →