RCN3

Across TCGA cell cohorts, RCN3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RCN3-associated genes across cancer lineages are CELA2A, MSGN1, and PPP1R42. Each is linked with RCN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCN3-to-partner and partner-to-RCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA2A grouped by RCN3-low versus RCN3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCN3→partner) and Y-score (partner→RCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CELA2A →	+0.056	+4.684	<.001	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	PPP1R42 →	+0.098	+3.781	.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.279	+3.196	<.001	.007	3	1
LARGE_INTESTINE	TBX5 →	+0.251	+3.626	.001	.006	3	1
BLOOD_Leukemia	DMRTC2 →	+0.023	+4.539	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CELA2A by RCN3 expression — SKIN

Explore this box plot interactively →