RCC2

Across TCGA patient cohorts, RCC2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCC2-associated genes across cancer lineages are INPP4B, p62 Lck ligand, and EGFR_pY1068. Each is linked with RCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCC2-to-partner and partner-to-RCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by RCC2-low versus RCC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC2→partner) and Y-score (partner→RCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.343	-2.807	.010	.003	3	2
UCEC	p62 Lck ligand →	+0.687	+2.916	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.269	-3.169	.009	.018	3	1
UCEC	eIF4E →	+0.253	+4.087	.003	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.449	.028	.019	3	1
UCEC	GAPDH →	+0.465	+2.999	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

INPP4B by RCC2 expression — UCEC

Explore this box plot interactively →