RCC2

Across TCGA cell cohorts, RCC2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RCC2-associated genes across cancer lineages are KRT84, UTF1, and C10orf53. Each is linked with RCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCC2-to-partner and partner-to-RCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT84 grouped by RCC2-low versus RCC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC2→partner) and Y-score (partner→RCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRT84 →	+0.464	+3.754	<.001	.002	3	1
LARGE_INTESTINE	UTF1 →	+0.015	+3.217	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.013	+3.217	<.001	.006	3	1
LARGE_INTESTINE	GSC2 →	+0.099	+3.103	<.001	.004	3	1
BLOOD_Leukemia	PRM2 →	+0.042	+5.554	<.001	<.001	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+4.037	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KRT84 by RCC2 expression — LARGE_INTESTINE

Explore this box plot interactively →