RCBTB2

Across TCGA patient cohorts, RCBTB2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCBTB2-associated genes across cancer lineages are Cyclin-B1, Src_pY527, and Caspase-7-cleavedD198. Each is linked with RCBTB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RCBTB2-to-partner and partner-to-RCBTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RCBTB2-low versus RCBTB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCBTB2→partner) and Y-score (partner→RCBTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.604	+2.087	.004	.005	3	3
UCEC	Src_pY527 →	-0.345	-1.990	.036	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.463	+1.894	.041	.030	3	2
UCEC	EGFR_pY1068 →	-0.258	-2.584	.007	.010	3	1
UCEC	eIF4G →	+0.278	+2.459	.019	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.101	-1.690	.035	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Cyclin-B1 by RCBTB2 expression — UCEC

Explore this box plot interactively →