RCAN3

Across TCGA cell cohorts, RCAN3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RCAN3-associated genes across cancer lineages are AGXT2, SPATA48, and PROP1. Each is linked with RCAN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCAN3-to-partner and partner-to-RCAN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGXT2 grouped by RCAN3-low versus RCAN3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCAN3→partner) and Y-score (partner→RCAN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AGXT2 →	+0.012	+4.371	.006	.005	3	1
LUNG_NSCLC_LUAD	SPATA48 →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PROP1 →	+0.041	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	DEFB134 →	+0.051	+4.371	.006	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AGXT2 by RCAN3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →