RCAN1

Across TCGA patient cohorts, RCAN1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCAN1-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with RCAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCAN1-to-partner and partner-to-RCAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RCAN1-low versus RCAN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCAN1→partner) and Y-score (partner→RCAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.383	+3.000	.046	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.970	+3.189	.001	.010	3	1
UCEC	c-Met_pY1235 →	+0.142	+3.321	<.001	.010	3	1
UCEC	PDCD4 →	-0.678	-2.990	.005	.036	2	1
UCEC	Caspase-8 →	-0.265	-3.169	.044	.019	2	1
UCEC	4E-BP1 →	+0.419	+2.837	.003	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by RCAN1 expression — UCEC

Explore this box plot interactively →