RC3H2

Across TCGA pan-cancer cohorts, RC3H2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RC3H2’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where RC3H2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RC3H2 is over-expressed in tumor.

PDAC, HNSC, and CCRCC are the cancer types where RC3H2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RC3H2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.655	<.001	6	view →
HNSC	Female	All	+0.603	.035	4	view →
CCRCC	Male	All	+0.201	<.001	4	view →
LSCC	Male	All	+0.142	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RC3H2–PDAC

Open the PDAC breakdown →