RC3H1

Across TCGA pan-cancer cohorts, RC3H1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RC3H1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RC3H1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RC3H1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and CCRCC are the cancer types where RC3H1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RC3H1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.197	<.001	11	view →
COAD	All	All	−0.875	.006	5	view →
CCRCC	Male	All	+0.134	.001	3	view →
LUAD	All	All	−0.059	.049	1	view →
LSCC	All	All	+0.049	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RC3H1–HNSC

Open the HNSC breakdown →