RC3H1

Across TCGA patient cohorts, RC3H1 mutation is significantly associated with the RNA expression of many other genes, with 3,377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RC3H1-associated genes across cancer lineages are GUCA1B, NOCT, and BUB3. Each is linked with RC3H1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RC3H1-to-partner and partner-to-RC3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1B grouped by RC3H1-low versus RC3H1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RC3H1→partner) and Y-score (partner→RC3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCA1B →	+0.496	+1.947	<.001	.002	3	4
SKCM	NOCT →	+0.618	+3.341	.009	.005	3	3
SKCM	BUB3 →	+0.543	+3.328	.006	.005	3	3
UCEC	AOC2 →	+0.825	+1.468	<.001	.001	3	3
UCEC	NDUFAF5 →	+0.266	+1.707	.001	<.001	3	3
UCEC	VPS18 →	+0.448	+1.954	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,377 associations by consensus.

GUCA1B by RC3H1 expression — UCEC

Explore this box plot interactively →