RC3H1

Across TCGA patient cohorts, RC3H1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RC3H1-associated genes across cancer lineages are Akt_pT308, EGFR_pY1068, and MEK1. Each is linked with RC3H1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RC3H1-to-partner and partner-to-RC3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by RC3H1-low versus RC3H1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RC3H1→partner) and Y-score (partner→RC3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.471	+1.807	.016	.024	3	2
UCEC	EGFR_pY1068 →	-0.197	-1.201	.011	.028	3	2
UCEC	MEK1 →	+0.362	+2.321	.001	<.001	3	2
UCEC	p53 →	-0.283	-1.502	.018	.027	3	2
UCEC	Shc_pY317 →	-0.148	-1.415	.001	.010	3	2
UCEC	ATM →	-0.619	-2.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Akt_pT308 by RC3H1 expression — UCEC

Explore this box plot interactively →