RC3H1

Across TCGA cell cohorts, RC3H1 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RC3H1-associated genes across cancer lineages are SCTR, FSHB, and GP9. Each is linked with RC3H1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RC3H1-to-partner and partner-to-RC3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCTR grouped by RC3H1-low versus RC3H1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RC3H1→partner) and Y-score (partner→RC3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCTR →	+0.220	+3.706	<.001	.005	3	1
CNS	FSHB →	+0.025	+5.321	<.001	.005	3	1
CNS	GP9 →	+0.025	+5.754	<.001	.002	3	1
CNS	PRAMEF26 →	+0.270	+5.754	.005	.002	3	1
BLOOD_Leukemia	GZMK →	+0.440	+4.037	.005	.004	3	1
BLOOD_Leukemia	ODF1 →	+0.066	+3.944	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

SCTR by RC3H1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →