RBX1

Across TCGA pan-cancer cohorts, RBX1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RBX1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RBX1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RBX1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where RBX1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBX1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+0.299	<.001	9	view →
HNSC	Male	III,IV	+0.235	<.001	7	view →
LSCC	All	All	+0.123	<.001	5	view →
PDAC	Female	II,III,IV	+0.252	<.001	4	view →
CCRCC	All	III,IV	+0.078	.004	4	view →
COAD	All	All	−0.078	.019	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RBX1–LUAD

Open the LUAD breakdown →