RBP4

Across TCGA patient cohorts, RBP4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBP4-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and Rad50. Each is linked with RBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBP4-to-partner and partner-to-RBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RBP4-low versus RBP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBP4→partner) and Y-score (partner→RBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.131	-2.986	.024	.037	3	1
UCEC	Heregulin →	-0.167	-3.000	.019	.037	3	1
UCEC	Rad50 →	-0.416	-3.000	.002	.037	3	1
UCEC	ASNS →	+0.894	+3.000	<.001	.036	3	1
UCEC	C-Raf →	+0.231	+3.000	.005	.037	3	1
UCEC	Di-Ras3 →	-0.170	-3.000	.047	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

14-3-3_beta by RBP4 expression — UCEC

Explore this box plot interactively →