Across TCGA pan-cancer cohorts, RBMY1J RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RBMY1J’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RBMY1J RNA is repressed in tumor relative to normal tissue. In most cancer types RBMY1J is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
LUSC and LUAD are the cancer types where RBMY1J tumor–normal differential expression is most reproducible.