RBMXL3

Across TCGA patient cohorts, RBMXL3 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBMXL3-associated genes across cancer lineages are Annexin-1, Smad4, and GAPDH. Each is linked with RBMXL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBMXL3-to-partner and partner-to-RBMXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RBMXL3-low versus RBMXL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBMXL3→partner) and Y-score (partner→RBMXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.585	+2.058	<.001	<.001	3	3
COAD	Smad4 →	+0.141	+3.700	.004	.001	3	3
COAD	GAPDH →	+0.494	+2.012	.008	.017	3	2
UCEC	MSH6 →	-0.344	-1.289	<.001	.018	3	2
COAD	PDCD4 →	-0.359	-1.798	.021	.026	3	2
COAD	ATM →	-0.520	-3.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Annexin-1 by RBMXL3 expression — UCEC

Explore this box plot interactively →