RBMXL2

Across TCGA cell cohorts, RBMXL2 mutation is significantly associated with the RNA expression of many other genes, with 259 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBMXL2-associated genes across cancer lineages are GUCA1C, SLC9C1, and AQP12A. Each is linked with RBMXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBMXL2-to-partner and partner-to-RBMXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1C grouped by RBMXL2-low versus RBMXL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBMXL2→partner) and Y-score (partner→RBMXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA1C →	+0.019	+3.969	<.001	.009	3	1
BLOOD_Leukemia	SLC9C1 →	+0.176	+4.017	<.001	.002	3	1
BLOOD_Leukemia	AQP12A →	+0.075	+3.684	<.001	.004	3	1
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	1
BLOOD_Leukemia	ACSM4 →	+0.028	+3.234	.009	.008	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.022	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 259 associations by consensus.

GUCA1C by RBMXL2 expression — BLOOD_Leukemia

Explore this box plot interactively →