RBMS3

Across TCGA patient cohorts, RBMS3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBMS3-associated genes across cancer lineages are eIF4E, PCNA, and ATM. Each is linked with RBMS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBMS3-to-partner and partner-to-RBMS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RBMS3-low versus RBMS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBMS3→partner) and Y-score (partner→RBMS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.157	+3.472	.018	.002	3	2
UCEC	PCNA →	+0.221	+1.584	.001	.005	3	2
UCEC	ATM →	-0.450	-2.986	.001	<.001	3	2
UCEC	Caspase-8 →	-0.278	-2.432	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.555	+2.415	.001	.002	3	2
UCEC	14-3-3_beta →	-0.088	-2.088	.005	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by RBMS3 expression — UCEC

Explore this box plot interactively →