RBM8A

Across TCGA patient cohorts, RBM8A mutation is significantly associated with the RNA expression of many other genes, with 1,479 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM8A-associated genes across cancer lineages are MIR6726, RNU6-1222P, and RN7SL150P. Each is linked with RBM8A in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM8A-to-partner and partner-to-RBM8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6726 grouped by RBM8A-low versus RBM8A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM8A→partner) and Y-score (partner→RBM8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6726 →	+0.745	+7.810	<.001	<.001	3	3
BRCA	RNU6-1222P →	+0.563	+6.950	<.001	<.001	3	2
BRCA	RN7SL150P →	+0.256	+5.020	<.001	.009	3	2
BLCA	MIR5089 →	+0.996	+3.719	<.001	.008	3	2
BLCA	MIR4479 →	+1.002	+4.506	<.001	.002	3	2
BLCA	MIR98 →	+0.378	+4.192	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,479 associations by consensus.

MIR6726 by RBM8A expression — SKCM

Explore this box plot interactively →