RBM7

Across TCGA patient cohorts, RBM7 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM7-associated genes across cancer lineages are 14-3-3_beta, ERK2, and GSK3-a-b. Each is linked with RBM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM7-to-partner and partner-to-RBM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RBM7-low versus RBM7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM7→partner) and Y-score (partner→RBM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.123	-3.143	.008	.018	3	1
UCEC	ERK2 →	+0.220	+3.700	.014	.001	3	1
UCEC	GSK3-a-b →	+0.134	+3.000	.033	.036	3	1
UCEC	JNK2 →	+0.290	+3.179	.001	.010	3	1
UCEC	MEK1 →	+0.425	+2.584	.012	.011	3	1
UCEC	p62 Lck ligand →	+0.305	+2.584	.044	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by RBM7 expression — UCEC

Explore this box plot interactively →