RBM6

Across TCGA patient cohorts, RBM6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM6-associated genes across cancer lineages are STAT3_pY705, FOXO3a_pS318_S321, and PCNA. Each is linked with RBM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM6-to-partner and partner-to-RBM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by RBM6-low versus RBM6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM6→partner) and Y-score (partner→RBM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.326	-1.916	<.001	.004	3	3
UCEC	FOXO3a_pS318_S321 →	-0.086	-1.459	.033	.012	3	2
UCEC	PCNA →	+0.238	+2.906	<.001	.001	3	2
UCEC	TFRC →	+0.390	+2.584	.023	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.528	+1.867	.006	.004	3	2
UCEC	4E-BP1 →	+0.374	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

STAT3_pY705 by RBM6 expression — UCEC

Explore this box plot interactively →