RBM6

Across TCGA cell cohorts, RBM6 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBM6-associated genes across cancer lineages are GCAT, HSCB, and CBY1. Each is linked with RBM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM6-to-partner and partner-to-RBM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by RBM6-low versus RBM6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM6→partner) and Y-score (partner→RBM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.172	+2.502	.002	.005	3	1
LARGE_INTESTINE	HSCB →	+0.484	+2.502	.009	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.562	+2.588	.002	.004	3	1
LARGE_INTESTINE	DDHD1 →	+0.871	+2.502	<.001	.005	3	1
LARGE_INTESTINE	CHMP4B →	-0.632	-3.541	.001	.001	3	1
LARGE_INTESTINE	ADNP2 →	+0.857	+3.628	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

GCAT by RBM6 expression — LARGE_INTESTINE

Explore this box plot interactively →