RBM5

Across TCGA patient cohorts, RBM5 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM5-associated genes across cancer lineages are Bad_pS112, eEF2, and FoxM1. Each is linked with RBM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM5-to-partner and partner-to-RBM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bad_pS112 grouped by RBM5-low versus RBM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM5→partner) and Y-score (partner→RBM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bad_pS112 →	-0.220	-3.893	<.001	<.001	3	3
UCEC	eEF2 →	+0.326	+2.807	.007	.002	3	2
UCEC	FoxM1 →	+0.227	+1.807	.009	.004	3	2
UCEC	MIG-6 →	+0.125	+2.115	<.001	.016	3	2
UCEC	PDCD4 →	-0.524	-1.807	.001	.004	3	2
UCEC	PTEN →	-0.376	-1.514	.005	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Bad_pS112 by RBM5 expression — UCEC

Explore this box plot interactively →