RBM4B

Across TCGA patient cohorts, RBM4B mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM4B-associated genes across cancer lineages are MEK1, TSC1, and Caspase-7-cleavedD198. Each is linked with RBM4B in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM4B-to-partner and partner-to-RBM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RBM4B-low versus RBM4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM4B→partner) and Y-score (partner→RBM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.362	+3.169	.028	.019	3	2
UCEC	TSC1 →	-0.186	-3.000	.016	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.835	+3.189	.001	.010	3	2
UCEC	eEF2 →	+0.488	+3.459	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.236	-2.000	.037	.032	3	1
UCEC	JNK2 →	+0.276	+2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by RBM4B expression — UCEC

Explore this box plot interactively →