RBM46

Across TCGA patient cohorts, RBM46 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM46-associated genes across cancer lineages are MEK1, Cyclin-E2, and XBP1. Each is linked with RBM46 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM46-to-partner and partner-to-RBM46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RBM46-low versus RBM46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM46→partner) and Y-score (partner→RBM46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.436	+2.115	<.001	<.001	3	3
COAD	Cyclin-E2 →	+0.282	+3.178	.013	.010	3	3
SKCM	XBP1 →	-0.258	-2.000	.010	.029	3	2
UCEC	EGFR_pY1068 →	-0.205	-2.087	.009	.005	3	2
UCEC	FASN →	+0.319	+1.999	.010	.002	3	2
UCEC	FoxM1 →	+0.208	+1.584	.010	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

MEK1 by RBM46 expression — UCEC

Explore this box plot interactively →