RBM45

Across TCGA patient cohorts, RBM45 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM45-associated genes across cancer lineages are FoxM1, MEK1, and NDRG1_pT346. Each is linked with RBM45 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM45-to-partner and partner-to-RBM45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RBM45-low versus RBM45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM45→partner) and Y-score (partner→RBM45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.249	+1.906	.016	.016	3	1
UCEC	MEK1 →	+0.302	+1.906	.040	.016	3	1
UCEC	NDRG1_pT346 →	-0.390	-3.169	.048	.018	3	1
UCEC	Notch1 →	+0.220	+3.713	<.001	<.001	3	1
UCEC	Annexin-1 →	+0.489	+2.341	.021	.019	3	1
UCEC	S6_pS240_S244 →	+0.326	+1.906	.046	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FoxM1 by RBM45 expression — UCEC

Explore this box plot interactively →