RBM42

Across TCGA patient cohorts, RBM42 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM42-associated genes across cancer lineages are Rad50, MEK1, and PRDX1. Each is linked with RBM42 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM42-to-partner and partner-to-RBM42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by RBM42-low versus RBM42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM42→partner) and Y-score (partner→RBM42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.328	-3.156	.001	.018	3	2
UCEC	MEK1 →	+0.525	+2.906	<.001	.001	3	1
UCEC	PRDX1 →	+0.173	+2.459	.048	.019	3	1
UCEC	S6_pS240_S244 →	+0.427	+2.820	.013	.035	3	1
UCEC	eIF4E →	+0.200	+1.700	.025	.044	2	1
UCEC	PCNA →	+0.240	+2.906	.008	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Rad50 by RBM42 expression — UCEC

Explore this box plot interactively →