RBM41

Across TCGA pan-cancer cohorts, RBM41 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RBM41 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher RBM41 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RBM41 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, HNSC, and SKCM are the cancer types where RBM41 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.010	0.844	<.001	36	view →
HNSC	OS	Median	III,IV	0.010	0.746	<.001	24	view →
SKCM	OS	Median	All	0.174	0.781	<.001	16	view →
ACC	DFS	Median	All	0.066	0.667	.002	12	view →
UCEC	DFS	Median	All	0.965	0.628	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RBM41–OV (OS)

Open the OV breakdown →