RBM41

Across TCGA patient cohorts, RBM41 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM41-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with RBM41 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM41-to-partner and partner-to-RBM41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RBM41-low versus RBM41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM41→partner) and Y-score (partner→RBM41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.222	-1.584	.013	.019	3	1
UCEC	A-Raf_pS299 →	-0.119	-1.807	.005	.025	3	1
UCEC	ERK2 →	+0.206	+2.807	.002	.003	3	1
UCEC	MEK1 →	+0.421	+2.807	.001	.003	3	1
UCEC	MSH2 →	-0.198	-2.089	.017	.016	3	1
UCEC	p27_pT198 →	+0.079	+1.584	.039	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by RBM41 expression — UCEC

Explore this box plot interactively →