RBM4

Across TCGA patient cohorts, RBM4 mutation is significantly associated with the RNA expression of many other genes, with 659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM4-associated genes across cancer lineages are NCR1, TRAJ21, and RNU6-6P. Each is linked with RBM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM4-to-partner and partner-to-RBM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCR1 grouped by RBM4-low versus RBM4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM4→partner) and Y-score (partner→RBM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NCR1 →	+0.524	+3.223	<.001	.009	3	2
COAD	TRAJ21 →	+1.098	+3.408	<.001	<.001	3	2
COAD	RNU6-6P →	+0.580	+3.099	<.001	.001	3	2
UCEC	SRCIN1 →	-0.851	-3.700	.001	.001	3	2
UCEC	CPT2 →	+0.563	+3.329	.005	.005	3	2
UCEC	CFTR →	-1.239	-3.451	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

NCR1 by RBM4 expression — COAD

Explore this box plot interactively →