RBM4

Across TCGA patient cohorts, RBM4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM4-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and p62 Lck ligand. Each is linked with RBM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM4-to-partner and partner-to-RBM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RBM4-low versus RBM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM4→partner) and Y-score (partner→RBM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.543	+3.459	.003	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.918	+3.169	.002	.018	3	2
UCEC	p62 Lck ligand →	+0.527	+2.321	.001	.035	3	1
UCEC	PDCD4 →	-0.629	-2.321	.007	.035	3	1
UCEC	PI3K-p85 →	+0.221	+2.321	.035	.035	3	1
UCEC	VHL →	-0.957	-3.169	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by RBM4 expression — UCEC

Explore this box plot interactively →