RBM25

Across TCGA patient cohorts, RBM25 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM25-associated genes across cancer lineages are ERK2, Shc_pY317, and ATM. Each is linked with RBM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM25-to-partner and partner-to-RBM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RBM25-low versus RBM25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM25→partner) and Y-score (partner→RBM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.170	+1.906	.007	.014	3	2
UCEC	Shc_pY317 →	-0.167	-2.502	<.001	.001	3	2
UCEC	ATM →	-0.476	-2.209	.001	.009	3	2
UCEC	Gab2 →	+0.255	+1.392	.030	.019	3	1
UCEC	INPP4B →	-0.262	-3.807	.014	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.169	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ERK2 by RBM25 expression — UCEC

Explore this box plot interactively →