RBM25

Across TCGA cell cohorts, RBM25 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBM25-associated genes across cancer lineages are OR8B3, OR6M1, and FBXL2. Each is linked with RBM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM25-to-partner and partner-to-RBM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B3 grouped by RBM25-low versus RBM25-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM25→partner) and Y-score (partner→RBM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR8B3 →	+0.019	+4.044	.005	.009	3	2
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1
LARGE_INTESTINE	FBXL2 →	-0.850	-3.278	.006	.006	3	1
LARGE_INTESTINE	FAM102B →	+0.847	+3.169	.006	.009	3	1
LARGE_INTESTINE	C1orf115 →	+1.206	+3.364	.008	.002	3	1
LARGE_INTESTINE	DDX20 →	+0.419	+3.364	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR8B3 by RBM25 expression — LUNG_SCLC

Explore this box plot interactively →