RBM22

Across TCGA patient cohorts, RBM22 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM22-associated genes across cancer lineages are PI3K-p110-a, eEF2, and MEK1. Each is linked with RBM22 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM22-to-partner and partner-to-RBM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by RBM22-low versus RBM22-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM22→partner) and Y-score (partner→RBM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PI3K-p110-a →	+0.200	+3.000	.023	.036	3	1
UCEC	eEF2 →	+0.404	+2.459	.019	.020	3	1
UCEC	MEK1 →	+0.421	+2.459	.017	.020	3	1
UCEC	Notch1 →	+0.217	+3.183	.001	.009	3	1
UCEC	RBM15 →	+0.321	+2.472	.037	.011	3	1
UCEC	STAT3_pY705 →	-0.482	-3.311	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PI3K-p110-a by RBM22 expression — SKCM

Explore this box plot interactively →