Across TCGA patient cohorts, RBM20 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM20-associated genes across cancer lineages are MSH6, Annexin-1, and Caspase-7-cleavedD198. Each is linked with RBM20 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM20-to-partner and partner-to-RBM20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM20→partner) and Y-score (partner→RBM20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.279	-1.584	.018	.019	3	2
UCEC	Annexin-1 →	+0.561	+2.222	.003	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.741	+1.827	<.001	.015	3	2
UCEC	eEF2 →	+0.395	+2.115	.002	.016	3	1
UCEC	EGFR_pY1068 →	-0.359	-2.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.168	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

RBM20 survival (RNA) · tumor vs normal (RNA) · all RBM20 data types