RBM19

Across TCGA patient cohorts, RBM19 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM19-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with RBM19 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM19-to-partner and partner-to-RBM19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RBM19-low versus RBM19-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM19→partner) and Y-score (partner→RBM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.506	+2.841	<.001	.033	3	3
UCEC	Caspase-7-cleavedD198 →	+0.695	+2.682	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.080	-2.558	.011	.010	3	2
UCEC	eIF4E →	+0.159	+1.584	.016	.005	3	2
UCEC	A-Raf_pS299 →	-0.089	-1.584	.017	.034	3	2
UCEC	GAPDH →	+0.393	+1.440	.020	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eEF2 by RBM19 expression — COAD

Explore this box plot interactively →