RBM19

Across TCGA cell cohorts, RBM19 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,697 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RBM19-associated GO terms across cancer lineages are Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA 5'-end processing, and Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with RBM19 in more than 15 cancer types. Because this analysis shows association rather than direction, both RBM19-to-partner and partner-to-RBM19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by RBM19-low versus RBM19-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM19→partner) and Y-score (partner→RBM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.198	+1.112	.004	.007	3	16
LIVER	rRNA 5'-end processing →	+0.198	+1.112	.004	.007	3	16
URINARY_TRACT	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.110	+0.974	<.001	<.001	3	16
OESOPHAGUS	Nuclear export →	+0.105	+0.742	.001	.002	3	14
OESOPHAGUS	rRNA metabolic process →	+0.118	+0.877	.002	<.001	2	15
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.145	+0.941	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,697 associations by consensus.

Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by RBM19 expression — LIVER

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