RBM19

Across TCGA cell cohorts, RBM19 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RBM19-associated genes across cancer lineages are OR8B4, NPFFR1, and CALHM4. Each is linked with RBM19 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM19-to-partner and partner-to-RBM19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by RBM19-low versus RBM19-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM19→partner) and Y-score (partner→RBM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR8B4 →	+0.030	+4.357	<.001	.004	3	1
BLOOD_Leukemia	NPFFR1 →	+0.009	+2.774	.001	.006	3	1
BLOOD_Leukemia	CALHM4 →	+0.027	+3.684	<.001	<.001	3	1
BLOOD_Leukemia	GSTT4 →	+0.103	+3.529	<.001	<.001	3	1
OVARY	RESP18 →	+0.045	+5.196	<.001	.005	3	1
OVARY	KRTAP20-2 →	+0.117	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR8B4 by RBM19 expression — CNS

Explore this box plot interactively →