RBM17

Across TCGA patient cohorts, RBM17 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM17-associated genes across cancer lineages are EGFR, JNK_pT183_Y185, and LKB1. Each is linked with RBM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM17-to-partner and partner-to-RBM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by RBM17-low versus RBM17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM17→partner) and Y-score (partner→RBM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.187	-3.000	.009	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-2.459	.013	.019	3	1
UCEC	LKB1 →	-0.103	-3.000	.031	.036	3	1
UCEC	Notch1 →	+0.203	+2.000	.001	.032	3	1
UCEC	AR →	-0.372	-2.000	.027	.032	3	1
UCEC	Tuberin →	+0.286	+2.700	.018	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR by RBM17 expression — UCEC

Explore this box plot interactively →