RBM15

Across TCGA patient cohorts, RBM15 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM15-associated genes across cancer lineages are eEF2, P-Cadherin, and ATM. Each is linked with RBM15 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM15-to-partner and partner-to-RBM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RBM15-low versus RBM15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM15→partner) and Y-score (partner→RBM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.261	+2.999	.047	.035	3	3
UCEC	P-Cadherin →	-0.127	-1.700	.016	.040	3	3
UCEC	ATM →	-0.497	-1.847	.002	.008	3	3
UCEC	FoxM1 →	+0.206	+1.502	.030	.030	3	2
UCEC	INPP4B →	-0.233	-1.700	.049	.040	3	2
UCEC	JNK2 →	+0.211	+3.469	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by RBM15 expression — UCEC

Explore this box plot interactively →